Prostate

• GnRH Agonists
• MOA: Binds to GnRH receptor, causes initial release of FSH/LH followed by suppresion
• Leuprolide, Goserelin, Triptorelin, Buserelin, Histrelin
• Need anti-androgen too, at least for 1^st 7 days, may make it worse
• GnRH Antagonists
• MOA: Binds to GnRH receptor and suppresses activity without initial increase in activit seen with GnRH agonists
• Degarelix, Relugolix
• Antiandrogen
• Bicalutamide
• Flutamide
• CYP17 Inhibitors
• Abiraterone + Prednisone
• Androgen Receptor Blockade
• Enzalutamide
• Apalutamide
• Tumor Vaccine
• Sipuleucel-T
• Chemotherapeutic
• MOA: Anti-microtubule agent
• Docetaxel/Cabazitaxel + Prednisone