MOA: Inhibit binding of histamine, released from enterochromaffin-like cells, at the H2 receptor on parietal cells and thus decreasing the hydrogen ion concentration in the stomach
General:
Work for 6-10 hours, greater efficacy and can be used for prophylaxis vs antacids
Famotidine (Pepcid)
Least likely too interfere with P450 enzymes
Ranitidine (Zantac)
Cimetidine (Tagamet)
Inhibits P450 enzymes
Proton Pump Inhibitors (PPIs)
MOA: Decreases hydrogen ion concentration in the stomach by inhibiting the H+/K+ ATPases on parietal cells
Only inhibit active proton pumps, leads to weak acid inhibition