Antidiarrheals

• CI: Bloody diarrhea, Fever
• Intestinal Adsorbents
• Bismuth
• Antipropulsives (opioids)
• General
  • Increase colonic phasic segmenting activity
• Crosses BBB:
  • Diphenoxylate
  • Combined with atropine to prevent abuse
  • Difenoxin
• Does not:
  • Eluxadoline (Viberzi)
  • Loperamide (Imodium)
  • No analgesia
• Anti-inflammatory
• Aminosalicylates
  • Sulfasalazine
  • Mesalamine
  • Olsalazine
• Other
• Octreotide
  • Thought to decrease the elevated pressure by decreasing splanchnic blood flow