Hematology/Oncology

Hematology¶

• Anemia
  • Anemia of Chronic Disease
    • Advancements in anemias related to chronic conditions
  • Transfusion thresholds
    • TRICC: Better survival in critically ill with Hgb target of >7 than >10
    • TRISS: Similar mortality with Hgb target of >7 than >9 in septic shock
• Breast Cancer
  • ATLAS: In ER+ BC, tamoxifen for 10 years reduced recurrence/mortality, increased endometrial cancer and PE risk
• Chronic Leukemia
  • CLL
    • Ibrutinib-Rituximab > FCR if <70 y/o and untreated
  • CML
    • IRIS: Imantinib > IFNa/cytarabine in delaying disease progression
• DIC
• General
  • Multiple CTs increase risk of leukemia and brain tumors
• Iron Deficiency Anemia
  • Consensus Statement on Peri-operative management of Anemia and IDA
  • IRONMAN: IV Iron not better than placebo, did not change # of pRBC transfusion during stay
• Lymphomas
• Thrombocytopenia
  • EDTA-dependent pseudothrombocytopenia: further insights and recommendations for prevention of a clinically threatening artifact
  • Drug-induced thrombocytopenia
    • PubMed
• VTE
  • SOME: Not better to screen for occult malignancy in first unprovoked VTE
  • AMPLIFY: Oral Apixaban for the Treatment of Acute VTE
  • PE
    • Causes of Elevated D-Dimer
    • ADJUST-PE: Age-adjusted D-Dimer (Age x 10) in patients >50 r/o more pts
    • ERC/PROPER: Low suspicion and PERC(-) reduces VTE probability to <2%
      • Also
    • PIOPED II: CTA is sensitive (90%) and specific (95%) for PE
  • DVT
    • Wells DVT Criteria
      • Rule-Out with Negative D-Dimer
      • Diagnosis/Treatment
      • Treatment
    • CLOT: Dalteparin > Warfarin in preventing recurrent VTE of malignancy

Oncology¶

• Breast Cancer
• Chemotherapy
  • General
    • Increased risk of MDS, Mixed MDS/MPN, and AML (10-20% of all cases of these cancers are chemotherapy related)
      • Therapy-Related Myeloid Leukemia
      • Etiology and management of therapy-related myeloid leukemia
  • Common Regimens
    • ABVD
      • Adriamycin, Bleomycin, Vinblastine, Dacarbazine
      • Hodgkin Lymphoma
    • BEACOPP
      • Bleomycin, Etoposide, Adriamycin/doxorubicin, Cyclophosphamide, Oncovorin/vincristine, Procarbazine, Prednisone
      • Hodgkin Lymphoma
    • FOLFIRI
      • Leucovorin, 5-Fluorouracil, Irinotecan
      • Advanced-stage and Metastatic Colorectal Cancer
    • FOLFOX
      • Leucovorin, 5-Fluorouracil, Oxaliplatin
    • R-CHOP
      • Rituximab, Cyclophosphamide, Hydroxy-doxorubicin, Oncovorin/Vincristine, Prednisone